Here, in pictures, is how their last dozen meetings in the annual championship went ...
9. Scotland v Wales in Six Nations
2012: Wales 27, Scotland 13
A try by Greig Laidlaw, plus a conversion and two penalties, couldn't stop their hosts heading for a third grand slam in eight years. Pictured is Greig Laidlaw in action during that RBS Six Nations game between Wales and Scotland at the Millennium Stadium on February 12, 2012, in Cardiff. (Photo by Stu Forster/Getty Images) Photo: Stu Forster
10. Scotland v Wales in Six Nations
2011: Scotland 6, Wales 24
Shane Williams scored two tries for the visitors as they headed for a fourth-place finish in that year's championship with six points, four more than fifth-placed Scotland. Pictured is Allan Jacobson of Scotland being tackled by Lee Byrne of Wales during that RBS Six Nations match at Murrayfield on February 12, 2011, in Edinburgh. (Photo by Jeff J Mitchell/Getty Images) Photo: Jeff J Mitchell
11. Scotland v Wales in Six Nations
2010: Wales 31, Scotland 24
Former Gala star Chris Paterson notched up his 100th Scotland cap as the national side headed for a fifth-place finish in that year's championship on three points, one behind fourth-placed Wales. Paterson is pictured at the Millennium Stadium on February 13, 2010, in Cardiff. (Photo by Stu Forster/Getty Images) Photo: Stu Forster
12. Scotland v Wales in Six Nations
2009: Scotland 13, Wales 26
Max Evans scored Scotland's only try as they headed for a fifth-place championship finish on two points, four behind fourth-placed Wales. Sean Lamont of Scotland is pictured being tackled by Martyn Williams of Wales during that match at Murrayfield Stadium on February 8, 2009, in Edinburgh. (Photo by David Rogers/Getty Images) Photo: David Rogers