Here, in pictures, is how their last dozen meetings in the annual championship went ...
5. Scotland v Wales in Six Nations
2016: Wales 27, Scotland 23
Captain Greig Laidlaw scored three penalties and converted a try but that wasn't enough to stop the Scots slumping to their ninth Six nations loss on the trot. Pictured is Finn Russell in action during that RBS Six Nations match at the Principality Stadium on February 13, 2016, in Cardiff. (Photo by Stu Forster/Getty Images) Photo: Stu Forster
6. Scotland v Wales in Six Nations
2015: Scotland 23, Wales 26
Stuart Hogg and Jon Welsh scored tries for the Scots and Jedburgh's Greig Laidlaw put away three penalties and a conversion, but Wales ended up just in front. Hogg is pictured breaking away to score the opening try during the RBS Six Nations match between Scotland and Wales at Murrayfield Stadium on February 15, 2015, in Edinburgh. (Photo by David Rogers/Getty Images) Photo: David Rogers
7. Scotland v Wales in Six Nations
2014: Wales 51, Scotland 3
A Greig Laidlaw penalty was scant consolation for Scotland as they suffered their biggest defeat to the Welsh since going down 46-22 in 2005. Pictured is Stuart Hogg being shown a yellow card after commiting a dangerous tackle during the RBS Six Nations match between Wales and Scotland at the Millennium Stadium on March 15, 2014 in Cardiff. (Photo by Laurence Griffiths/Getty Images) Photo: Laurence Griffiths
8. Scotland v Wales in Six Nations
2013: Scotland 18, Wales 28
Greig Laidlaw put away six out of eight penalties for Scotland but that was bested by Leigh Halfpenny's tally of seven from ten, plus a conversion. Pictured is Laidlaw taking a penalty kick at that game at Murrayfield in Edinburgh on March 9, 2013. (Photo: Ian MacNicol/AFP via Getty Images) Photo: IAN MACNICOL