They play the current world champions at Marseille’s Stade Vélodrome on Sunday, September 10, 2023.
That will be the third time the two sides have faced each other in the competition, the Springboks having won both previous meetings, 46-29 at Edinburgh’s Murrayfield Stadium in October 1999 and 34-16 at Newcastle’s St James’s Park in October 2015.
To date, the two sides have played each other 27 times, beginning in 1906, with South Africa winning 22 of those games and the Scots five.
They’re also due to meet each other in an autumn international at Edinburgh’s Murrayfield Stadium on a date yet to be decided in November.
It’s over ten years since the Scots last beat the world’s top-ranked side, courtesy of six penalties and a drop-goal from Australian-born stand-off Dan Parks to secure a 21-17 victory in 2010, also in an autumn international.
Scotland head coach Gregor Townsend said: “Fans, players and coaches will be looking forward to seeing Scotland face southern hemisphere opposition in Australia and the current world champions, South Africa, at BT Murrayfield.
“The autumn internationals in 2021 will be another opportunity for our players to represent their country, hopefully with our fans in attendance, and provide the team with a different challenge and exciting challenge."
Ahead of the two meetings the Scots have lined up with the Springboks, here’s a look back at their last dozen games ...

. NEWCASTLE UPON TYNE, ENGLAND - OCTOBER 03: Stuart Hogg of Scotland during the Rugby World Cup 2015 Pool B match between South Africa and Scotland at St James Park on October 03, 2015 in Newcastle upon Tyne, England. (Photo by Steve Haag/Gallo Images)
Current Scotland captain Stuart Hogg on the ball during his side's 2015 Rugby World Cup pool-B match against South Africa at St James's Park in Newcastle on October 3, 2015 (Photo by Steve Haag/Gallo Images) Photo: Gallo Images

. Scotland v South Africa
Scotland 20, South Africa 26: November 17, 2018, autumn international Former Melrose player Peter Horne scoring Scotland's first try during an international friendly against South Africa at Murrayfield Stadium in Edinburgh (Photo by Ian MacNicol/Getty Images) Photo: Ian MacNicol

1. Scotland v South Africa
Scotland 20, South Africa 26: November 17, 2018, autumn international Former Melrose player Peter Horne scoring Scotland's first try during an international friendly against South Africa at Murrayfield Stadium in Edinburgh (Photo by Ian MacNicol/Getty Images) Photo: Ian MacNicol

2. Scotland v South Africa
South Africa 34, Scotland 16: October 3, 2015, Rugby World Cup Scotland captain Greig Laidlaw preparing to take a penalty kick during his side's pool-B match against South Africa at St James's Park in Newcastle (Photo: Paul Ellis/AFP via Getty Images) Photo: PAUL ELLIS

3. Scotland v South Africa
South Africa 55, Scotland 6: June 28, 2014, summer test Scotland's Stuart Hogg on the ball during a tour match versus South Africa at Nelson Mandela Bay Stadium in Port Elizabeth (Photo by Steve Haag/Gallo Images/Getty Images) Photo: Gallo Images

4. Scotland v South Africa
Scotland 0, South Africa 28: November 17, 2013, autumn international Greig Laidlaw of Scotland passing the ball at Murrayfield Stadium in Edinburgh (Photo by David Rogers/Getty Images) Photo: David Rogers