The A68 will close from south of Soutra Mains Quarry to the Ravenswood roundabout between 8pm and 6am on those dates.
A diversion route will be signposted between the roundabout, north of St Boswells, and the A68, north of Fala Village, via the A6091, the A7, the B6367 and the B6458.
A spokesman for roads contractor Amey said: “These essential works, with a value of £176,000, will improve safety and journey time reliability, as well as reduce the need for further disruptive maintenance. All schemes are weather dependent and may be cancelled or rescheduled.”