In all four people were injured in the two-vehicle crash between Bonjedward and Cleikhimin, which was reported to police at around 8am.
Firefighter cut both drivers free from their cars after the collision, and one, a 69-year-old woman, was taken to Edinburgh Royal Infirmary.
Her injuries were said to be “serious but not life -threatening”.
The other driver, a 24-year-old man, was taken to Borders General Hospital for checks, along with two passengers.
The A68 road between Bonjedward and Cleikhimin wasclosed for police to begin their investigations until 3.50pm.