David Bowie allegedly refrigerated it to ward off evil and in the trenches of Ypres in the First World War, soldiers used it as a gas mask.
Cloth makers from the Romans to weavers on the Isle of Harris have depended on it.
And it will be the topic of discussion when BBC Scotland presenter Sally Magnusson talks about her book Life of Pee in Kelso next month, where she will unveil the secret history of civilisation’s most unsavoury and unsung hero.
She will also give a passionate plea for pee to take its place at the cutting edge of green revolution.
Sally Magnusson is at the Cross Keys Hotel for the Friends of Kelso Library event on Monday, April 2, at 7pm. Tickets cost £7.50 and more information is available from 01573 223171.