Former Selkirk centre Alex Dunbar will earn his first Scotland cap on Saturday against Samoa in Durban, South Africa.
The 23-year-old Glasgow Warrior is one of three new caps, alongside 24-year-old Edinburgh Rugby full-back Greig Tonks and Pat MacArthur, 26, also a Warrior.
Kelly Brown of Saracens and Greig Laidlaw of Edinburgh are the only Borderers in the starting line up, with Geoff Cross of Edinburgh on the bench.
In addition there are a further three uncapped players on the bench, Stevie Lawrie, Peter Horne and Duncan Taylor.
All in, there are five changes of personnel and one positional switch from Scotland’s last game – the defeat away to France, which rounded-off the RBS 6 Nations Championship in March.
Scotland head coach Scott Johnson said: “We want to broaden the base and it (selection) gives us the perfect opportunity to see how these guys stand up in Test footy.
“They have all the artillery coming for our game and we’re going out to compete on all fronts.
“We have 25 test matches available to us prior to the World Cup. I’ve said regularly that we’re not going to give test jerseys away but we cannot be exposed to injury issues and the best way to prevent that is to give players opportunities.”
The match kicks off at 1.15pm UK time.
Scotland: G. Tonks (Edinburgh), S. Lamont, A. Dunbar (both Glasgow Warriors), M. Scott, T. Visser (both Edinburgh), T. Heathcote (Bath), G. Laidlaw (Edinburgh); R. Grant, P. MacArthur (both Glasgow), E. Murray (Worcester Warriors), G. Gilchrist (Edinburgh), A. Kellock (Glasgow), A. Strokosch (Perpignan), K. Brown (Saracens), J. Beattie (Montpellier).
Subs: S. Lawrie (Edinburgh), A. Dickinson (Sale Sharks), G. Cross (Edinburgh), J. Hamilton (Gloucester), R. Wilson, H. Pyrgos, P. Horne (all Glasgow), D. Taylor (Saracens).