After having been high in the heavens through an impressive unbeaten run, Selkirk came back to earth last Saturday when falling 4-1 to Dalbeattie Star.
This weekend the Yarrow Park side bid to find the uphill trail in travelling to face East Kilbride, the recent 8-0 victors over Peebles Rovers.
Selkirk manager Stevie Forrest said: “It will be a difficult game as they are a good side.
“Fingers crossed though we can get back to playing the good football that we are capable of producing.”
Vale of Leithen, who have got the season off to a stuttering start, are away to league newcomers Cumbernauld Colts.
Peebles Rovers and Hawick Royal Albert clash in East of Scotland League business at Whitsestone Park. The two clubs have already met this season, with Hawick emerging surprise 1-0 winners in a Qualifying Cup encounter.
Peebles manager John O’Hara said: “We will be ready for them this time.
“In the last game we perhaps took them for granted but we won’t be making the same mistake as Hawick have improved a lot.”
Kelso United take on near neighbours Coldstream at Woodside Park.